We are interested in understanding how molecular assemblies work. In particular, we are fascinated by protein complexes that rearrange biological membranes to shape cell structure.
We watch protein molecules in action to understand:
How does cellular organization arise?
We reconstitute cellular events to understand how molecules coordinate activities.
How varied is molecular shape?
We visualize macromolecular assemblies as they work to understand functional roles for conformational heterogeneity.
How is molecular motion translated into cellular diversity?
We probe how evolution uses molecular switches to generate a cornucopia of cellular functions.
Department of Molecular Biology - MGH
Department of Genetics - HMS