2026

Navarro PP, Vettiger A, Hajdu R, Ananda VY, Lopez-Tavares A, Schmid EW, Walter JC, Loose M, Chao LH, Bernhardt TG. The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture. Nat Microbiol. 2026 Aug;11(8):2142-2156. 🔗 https://pubmed.ncbi.nlm.nih.gov/42399561/ (Preprint: bioRxiv 2025 Apr 2, PMID 40236067)

Alves CRR, Das S, Krishnan V, Ha LL, Fox LR, Stutzman HE, Shamber CE, Kalailingam P, McCarthy S, Lino Cardenas CL, Fong CE, Imai T, Mitra S, Yun S, Wood RK, Benning FMC, Roh K, Lawton J, Kim N, Silverstein RA, Ferreira da Silva J, de la Cruz D, Richa R, Xie J, Gray-Edwards HL, Malhotra R, Chung DY, Chao LH, Tsai SQ, Maguire CA, Lindsay ME, Kleinstiver BP, Musolino PL. Treatment of a severe vascular disease using a bespoke CRISPR-Cas9 base editor in mice. Nat Biomed Eng. 2026 May;10(5):952-967. 🔗 https://pubmed.ncbi.nlm.nih.gov/40935887/ (Preprint: bioRxiv 2024 Nov 11, PMID 39605323)

2025

Pelech P, Navarro PP, Vettiger A, Chao LH, Allolio C. Stress-mediated growth determines Escherichia coli division site morphogenesis. Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2424441122. 🔗 https://pubmed.ncbi.nlm.nih.gov/40632565/ (Preprint: bioRxiv 2024 Sep 12, PMID 39314472)

Benning FMC, Bell TA, Nguyen TH, Syau D, Connell LB, Liao YT, Keating MP, Coughlin M, Nordstrom AEH, Ericsson M, daCosta CJB, Chao LH. Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast. Protein Sci. 2025 Jul;34(7):e70207. 🔗 https://pubmed.ncbi.nlm.nih.gov/40545685/ (Preprint: bioRxiv 2025 May 17, PMID 38746426)

Ding C, Ndiaye PS, Campbell SR, Fry MY, Gong J, Wienbar SR, Gibbs W, Morquette P, Chao LH, Do MTH, Schwarz TL. SARM1 loss protects retinal ganglion cells in a mouse model of autosomal dominant optic atrophy. J Clin Invest. 2025 Jun 16;135(12):e191315. 🔗 https://pubmed.ncbi.nlm.nih.gov/40344041/

Sabbah HN, Alder NN, Sparagna GC, Bruce JE, Stauffer BL, Chao LH, Pitceathly RDS, Maack C, Marcinek DJ. Contemporary insights into elamipretide's mitochondrial mechanism of action and therapeutic effects. Biomed Pharmacother. 2025 Jun;187:118056. 🔗 https://pubmed.ncbi.nlm.nih.gov/40294492/

2024

Ferreira da Silva J, Tou CJ, King EM, Eller ML, Rufino-Ramos D, Ma L, Cromwell CR, Metovic J, Benning FMC, Chao LH, Eichler FS, Kleinstiver BP. Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases. Nat Biotechnol. 2025 Jun;43(6):923-935 (Epub 2024 Jul 22). 🔗 https://pubmed.ncbi.nlm.nih.gov/39039307/

Boopathy S, Luce BE, Lugo CM, Hakim P, McDonald J, Kim HL, Ponce J, Ueberheide BM, Chao LH. Identification of SLC25A46 interaction interfaces with mitochondrial membrane fusogens Opa1 and Mfn2. J Biol Chem. 2024 Oct;300(10):107740. 🔗 https://pubmed.ncbi.nlm.nih.gov/39222684/ (Preprint: bioRxiv 2024 Jul 27, PMID 38234813)

Bell TA, Luce BE, Hakim P, Ananda VY, Dardari H, Nguyen TH, Monshizadeh A, Chao LH. Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation. Elife. 2024 Aug 13;13:e100061. 🔗 https://pubmed.ncbi.nlm.nih.gov/39136554/ (Preprint: bioRxiv 2024 May 23, PMID 37986829)

Fry MY, Navarro PP, Hakim P, Ananda VY, Qin X, Landoni JC, Rath S, Inde Z, Lugo CM, Luce BE, Ge Y, McDonald JL, Ali I, Ha LL, Kleinstiver BP, Chan DC, Sarosiek KA, Chao LH. In situ architecture of Opa1-dependent mitochondrial cristae remodeling. EMBO J. 2024 Feb;43(3):391-413. 🔗 https://pubmed.ncbi.nlm.nih.gov/38225406/ (Preprint: bioRxiv 2023 Nov 9, PMID 36711707)

Benning FMC, Jenni S, Garcia CY, Nguyen TH, Zhang X, Chao LH. Helical reconstruction of VP39 reveals principles for baculovirus nucleocapsid assembly. Nat Commun. 2024 Jan 4;15(1):250. 🔗 https://pubmed.ncbi.nlm.nih.gov/38177118/ (Preprint: bioRxiv 2023 Nov 7, PMID 37398449)

2022

Navarro PP, Vettiger A, Ananda VY, Llopis PM, Allolio C, Bernhardt TG, Chao LH. Cell wall synthesis and remodelling dynamics determine division site architecture and cell shape in Escherichia coli. Nat Microbiol. 2022 Oct;7(10):1621-1634. 🔗 https://pubmed.ncbi.nlm.nih.gov/36097171/

Abdulaziz EN, Bell TA, Rashid B, Heacock ML, Begic T, Skinner OS, Yaseen MA, Chao LH, Mootha VK, Pierik AJ, Cracan V. A natural fusion of flavodiiron, rubredoxin, and rubredoxin oxidoreductase domains is a self-sufficient water-forming oxidase of Trichomonas vaginalis. J Biol Chem. 2022 Aug;298(8):102210. 🔗 https://pubmed.ncbi.nlm.nih.gov/35780837/

2021

Ge Y, Boopathy S, Nguyen TH, Lugo CM, Chao LH. Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion. Front Mol Biosci. 2021 Dec 22;8:769135. 🔗 https://pubmed.ncbi.nlm.nih.gov/35004847/

Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Nemeth I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemeny LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-Jose R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 Aug 5;184(16):4268-4283.e20. 🔗 https://pubmed.ncbi.nlm.nih.gov/34233163/

2020

Ge Y, Boopathy S, Smith A, Chao LH. A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics. J Vis Exp. 2020 Sep 2;(163). 🔗 https://pubmed.ncbi.nlm.nih.gov/32955498/

Sloutsky R, Dziedzic N, Dunn MJ, Bates RM, Torres-Ocampo AP, Boopathy S, Page B, Weeks JG, Chao LH, Stratton MM. Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation. Sci Signal. 2020 Jul 21;13(641):eaaz0240. 🔗 https://pubmed.ncbi.nlm.nih.gov/32694170/

Ge Y, Shi X, Boopathy S, McDonald J, Smith AW, Chao LH. Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane. Elife. 2020 Jan 10;9:e50973. 🔗 https://pubmed.ncbi.nlm.nih.gov/31922487/

2019

Chao LH, Avruch J. Cryo-EM insight into the structure of MTOR complex 1 and its interactions with Rheb and substrates. F1000Res. 2019 Jan 3;8. 🔗 https://pubmed.ncbi.nlm.nih.gov/30647914/

Tilley DC, Angueyra JM, Eum KS, Kim H, Chao LH, Peng AW, Sack JT. The tarantula toxin GxTx detains K+ channel gating charges in their resting conformation. J Gen Physiol. 2019 Mar 4;151(3):292-315. 🔗 https://pubmed.ncbi.nlm.nih.gov/30397012/

Post-doc and prior:

Chao LH, Jang J, Johnson A, Nguyen A, Gray NS, Yang PL, Harrison SC. How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion. Elife. 2018 Jul 12;7:e36461. 🔗 https://pubmed.ncbi.nlm.nih.gov/29999491/

Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang PL, Whelan SP, Ross SR, Kirchhausen T, Gaudin R. Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol. 2016 Apr 14;90(9):4494-4510. 🔗 https://pubmed.ncbi.nlm.nih.gov/26912630/

Chao LH, Klein DE, Schmidt AG, Pena JM, Harrison SC. Sequential conformational rearrangements in flavivirus membrane fusion. Elife. 2014 Dec 5;3:e04389. 🔗 https://pubmed.ncbi.nlm.nih.gov/25479384/

Stratton M, Lee IH, Bhattacharyya M, Christensen SM, Chao LH, Schulman H, Groves JT, Kuriyan J. Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity. Elife. 2014 Jan 28;3:e01610. 🔗 https://pubmed.ncbi.nlm.nih.gov/24473075/

Stratton MM, Chao LH, Schulman H, Kuriyan J. Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II. Curr Opin Struct Biol. 2013 Apr;23(2):292-301. 🔗 https://pubmed.ncbi.nlm.nih.gov/23632248/

Chao LH, Stratton MM, Lee IH, Rosenberg OS, Levitz J, Mandell DJ, Kortemme T, Groves JT, Schulman H, Kuriyan J. A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin-dependent kinase II holoenzyme. Cell. 2011 Sep 2;146(5):732-745. 🔗 https://pubmed.ncbi.nlm.nih.gov/21884935/

Chao LH, Pellicena P, Deindl S, Barclay LA, Schulman H, Kuriyan J. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat Struct Mol Biol. 2010 Mar;17(3):264-272. 🔗 https://pubmed.ncbi.nlm.nih.gov/20139983/

Young MA, Shah NP, Chao LH, Seeliger M, Milanov ZV, Biggs WH 3rd, Treiber DK, Patel HK, Zarrinkar PP, Lockhart DJ, Sawyers CL, Kuriyan J. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res. 2006 Jan 15;66(2):1007-1014. 🔗 https://pubmed.ncbi.nlm.nih.gov/16424036/

Nunn CM, Jeeves M, Cliff MJ, Urquhart GT, George RR, Chao LH, Tscuchia Y, Djordjevic S. Crystal structure of tobacco etch virus protease shows the protein C terminus bound within the active site. J Mol Biol. 2005 Jul 1;350(1):145-155. 🔗 https://pubmed.ncbi.nlm.nih.gov/15919091/