We seek to understand the structural and biophysical determinants of cellular membrane shape. A major goal is to understand the mitochondrion's remarkable morphology.

We're fascinated by the dialogue between protein machines and their environment. Proteins shape membranes by converting energy into motion. In turn, proteins respond to signals from their local membrane environment.

Mitochondria have an intricate membrane architecture - specialized and responsive to cell state. How does protein form regulate organelle function? We are interested in understanding how mitochondrial shape changes in different physiological states, tissues, and in disease.

Compartmentalization is a hallmark of life. Transmission of genetic material occurs in membrane-defined compartments. Membranes are reaction vessels for a wide range of specialized chemistries, and provide two-dimensional substrates to organize signaling.

Coordinating and communicating between membranes presents interesting challenges. How are lipid signals propagated while maintaining distinct membrane compositions? How do physical forces influence structural change across multiple membranes?

We are dedicated to capturing molecular structure with relevant context. How are the acrobatics of individual proteins choreographed in larger assemblies on membranes? Which conformational states are sampled by proteins in their native cellular environment? Mitochondria arose from an ancient endosymbiosis event at the origin of eukaryotic cells. We are also curious about how evolution shapes the regulation of membrane assemblies.

Interested in learning more? Come join us!