We apply an integrative approach to capture protein/membrane assemblies in action, with the goal of understanding the molecular basis for cell morphology.
The molecules of life do not operate in a vacuum. We're intrigued by how membrane lipid composition and distribution influences molecular and cellular motion. Cellular environments are an exciting frontier to understand molecular and cellular shape.
The molecules of life do not operate in a vacuum. We're intrigued by how membrane lipid composition and distribution influences molecular and cellular motion. Cellular environments are an exciting frontier to understand molecular and cellular shape.
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Structural Biology
We use electron cryo-microscopy (Cryo-EM) and X-ray crystallography to understand the structure of protein machines. Together with other biophysical methods, we explore the protein motions these assemblies undergo during their mechanical cycle. credit image: pdb 3KK8
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In vitro reconstitution
We use synthetic membrane systems to dissect molecular mechanism. We reconstitute protein assembly and activity in liposome and supported bilayer systems. Our goal is to recapture essential elements of membrane dynamics and structure from purified components. credit image: pdb 6GCI, 6B8H, Fawcett The Cell
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New Tools
We're interested in collaborations leveraging new tools to understand protein dynamics in cells. We explore approaches to visualize in situ cell morphology, to understand protein state in native contexts. credit image: pdb 3SOA
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